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Visualizing Cartilage and Joint Homeostasis Changes after Knee Joint Distraction using the META-Scanner and Synovial Fluid Aspirations*

Visualizing Cartilage and Joint Homeostasis Changes after Knee Joint Distraction using the META-Scanner and Synovial Fluid Aspirations* - META-scanner and SF-markers in KJD

Status
Unknown
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON48274
Enrollment
20
Registered
2019-07-24
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cartilage degeneration osteoarthritis

Interventions

None listed

Sponsors

Universitair Medisch Centrum Utrecht
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients with knee joint degeneration (osteoarthritis) eligible in regular clinical practice for knee joint distraction. In order to be eligible to participate in this study, a subject must meet all of the following criteria: - Good knowledge of the Dutch language - Signed informed consent

Exclusion criteria

Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: - Not eligible for MRI, in response to the MRI safety checklist - Metal present in the treated knee - Knee width > 14 cm

Design outcomes

Primary

MeasureTime frame
The changes in GAG content of the cartilage; the changes in joint homeostasis that facilitates cartilage repair after knee joint distraction, with a focus on growth factors, proteases, pro-inflammatory cytokines, and mesenchymal stem cells; the changes in sodium concentration of the cartilage.—

Secondary

MeasureTime frame
* Relation between imaging parameters and synovial fluid changes—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)