PET imaging of the noradrenaline system in healthy volunteers - a pilot study

PET imaging of the noradrenaline system in healthy volunteers - a pilot study - Noradrenaline system imaging

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON48264

Enrollment

Registered

2019-11-26

Start date

2020-03-03

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

het betreft gezonde vrijwilligers healthy volunteers

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: age between 50 and 80 years

Exclusion criteria

Exclusion criteria: - past or present developmental disorder or psychiatric disorder - abnormal results on the MMSE (

Design outcomes

Primary

Measure	Time frame
30-min static data can be derived, after acquisition, from the 90-min dynamic data. Several values will be computed and statistically compared against each other: NET binding potentials (BP), standardized uptake values (SUV) and K values will be computed for each region of interest (LC and projection areas), which will then be used to compute ratios using appropriate reference tissue models. Outcomes from both scan durations can be statistically compared. A non-significant result will show that the 30-min data is as reliable as the 90-min data.	—

Measure

Time frame

30-min static data can be derived, after acquisition, from the 90-min dynamic data. Several values will be computed and statistically compared against each other: NET binding potentials (BP), standardized uptake values (SUV) and K values will be computed for each region of interest (LC and projection areas), which will then be used to compute ratios using appropriate reference tissue models. Outcomes from both scan durations can be statistically compared. A non-significant result will show that the 30-min data is as reliable as the 90-min data.

—

Secondary

Measure	Time frame
Not applicable.	—

Countries

Netherlands

Outcome results