Long-term effects of mixed nuts consumption on brain vascular function in elderly men and women.

Long-term effects of mixed nuts consumption on brain vascular function in elderly men and women. - Mixed nuts and brain vascular function.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON48256

Enrollment

Registered

2019-12-11

Start date

2020-01-23

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Insulin Resistance Syndrome Metabolic Syndrome Syndrome X

Interventions

Subjects will receive in random order daily 60 g of mixed nuts (15 g of walnuts, 15 g of cashews, 15 g of hazelnuts, and 15 g of pistachios) (nut intervention) or no nuts for 16 weeks (control inter

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Aged between 60-70 years - BMI between 25-35 kg/m2 - Fasting plasma glucose

Exclusion criteria

Exclusion criteria: - Allergy or intolerance to nuts - Left handedness - Current smoker, or smoking cessation

Design outcomes

Primary

Measure	Time frame
At baseline, first anthropometric measurements will be performed and blood pressure will be determined. In addition, a fasting blood sample will be drawn. Another fasting blood sample will be draw at eight weeks, while participants have to attend the research facilities two times to perform follow-up measurements after sixteen weeks. The primary endpoint is the difference at follow-up in cerebral blood flow, as assessed by ASL, between interventions.	—

Measure

Time frame

At baseline, first anthropometric measurements will be performed and blood pressure will be determined. In addition, a fasting blood sample will be drawn. Another fasting blood sample will be draw at eight weeks, while participants have to attend the research facilities two times to perform follow-up measurements after sixteen weeks. The primary endpoint is the difference at follow-up in cerebral blood flow, as assessed by ASL, between interventions.

—

Secondary

Measure	Time frame
Secondary endpoints are the cerebral blood flow response to intranasal insulin delivery as quantified by ASL, and cognitive functioning as assessed with a neuropsychological test battery.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)