Developmental Language Disorder (DLD) speech/language disorder
Conditions
Interventions
None listed
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
2 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Diagnosis TOS (Developmental Language Disorder) given in the Netherlands - Age at inclusion: 4-18y - IQ>70 on non-verbal test - Indication for education at Cluster 2 school or ambulatory Cluster 2 support - Speech must be affected - A negative first-degree family history for speech and language disorders, speech therapy, autism spectrum disorders and special education
Exclusion criteria
Exclusion criteria: - An autism spectrum disorder diagnosis made by a child psychiatrist or GZ psychologist - Next generation sequencing (including WES) has already been performed, or is being performed at the time of inclusion - One biological parent is not available for genetic testing (or both biological parents are not available)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary objective of this study is to define the diagnostic yield of whole genome sequencing (WGS) in children with a severe DLD and a negative family history. | — |
Secondary
| Measure | Time frame |
|---|---|
| In addition to the primary study parameter, we aim to identify the genes in which variants are found to (possibly) cause DLD, the corresponding molecular pathways, the type of genetic variation involved. We also aim to identify possible patient subgroups within the cohort with a significantly different diagnostic yield. | — |
Countries
Netherlands
Outcome results
None listed