posttraumatic stress disorder anxiety disorder
Conditions
Interventions
tDCS (2.0 mA, 20 minutes per session) can promote neural activity and
plasticity in the cortical area underneath the anode (here: placed over the
right dorsolateral prefrontal cortex, rDLPFC), and i
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - 18-60 years of age - Uncorrected normal hearing - Provide written informed consent
Exclusion criteria
Exclusion criteria: - Alcohol or drug dependence - Use of illicit drugs or psychoactive medication within the past two weeks - Having a current psychiatric diagnosis - Having a current or previous neurological disorder, e.g., epilepsy, Parkinson*s disease. - Serious head trauma or brain surgery (N.B. TBI without brain damage or skull damage is no reason for exclusion) - Large or ferromagnetic metal parts in the head (except for a dental wire) - Implanted cardiac pacemaker or neurostimulator - Pregnancy - Concurrent or recent (within previous month) participation in a neuromodulation or neurostimulation (e.g., tDCS, TMS) experiment. - Skin damage or diseases at intended electrode sites (tDCS)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is the pre- to post-intervention change in measures of fear reactions (responses to threat of shock). | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcomes are the pre- to post-intervention changes in working memory (the dual N-back task that is also used for cognitive training), inhibitory control (emotional Go/Nogo task), and measures of neural activity (EEG) linked to cognitive regulation and emotional reactions. In addition, we will take into account the degree of anxiety sensitivity, anxiety symptoms and self-regulation skills, based on self-report psychological questionnaires. | — |
Countries
Netherlands
Outcome results
None listed