The iFAOd study-inflammatory response in long-chain Fatty Acid Oxidation disorders

The iFAOd study-inflammatory response in long-chain Fatty Acid Oxidation disorders - iFAOd

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON48223

Enrollment

Registered

2019-01-24

Start date

2020-09-24

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

deficiency in beta-oxidation of long-chain fat long-chain fatty acid oxidation disorder

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: -Enzymatically confirmed long-chain fatty acid oxidation disorder including VLCAD, LCHAD, MTP, CPT1, CPT2 and CACT deficiency -18 years old or older

Exclusion criteria

Exclusion criteria: (auto-) immunedisorder

Design outcomes

Primary

Measure	Time frame
* monocyte phenotype, including monocyte subset percentages and their expression of key surface proteins, including inflammatory and anti-inflammatory markers and receptors * Inflammatory responses, whole blood will be activated with the prototypical pro-inflammatory TLR4 trigger LPS (lipopolysaccharide) and production of cytokines will be assessed after 24 h (i.e. IL-6, TNF, IL-12, IL-8)	—

Secondary

Measure	Time frame
phenotype of other immune cells (e.g. neutrophils, T cells and B cells)	—

Countries

Netherlands

Outcome results