mental retardation Syndromal psychiatric disorder
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Probands must meet the following criteria: 1. All probands or their representatives must give signed informed consent; 2. Probands have a psychiatric disorder classified according to DSM-IV, DSM-5 or DIGS; 3. Probands are adults, i.e. 18 years of age or older.;Parental controls must meet the following criteria: 1. All parents or their representatives must give signed informed consent.;Healthy controls must meet the following criteria: 1. All healthy controls must give signed informed consent; 2. Healthy controls have no history of psychiatric illness according to DIGS; 3. Healthy controls are adults (i.e. 18 years of age or older), demographically-matched to probands on the basis of age, sex and ethnicity.
Exclusion criteria
Exclusion criteria: 1. Unable to give informed consent to all aspects of the study. 2. Unable to speak and be interviewed in Dutch or English (to ensure validity of the interviews). 3. Psychiatric symptoms are secondary to substance abuse; 4. Facial dysmorphology is not congenital.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quantification of the relationship between psychiatric pathogenic variants and facial dysmorphic features. | — |
Secondary
| Measure | Time frame |
|---|---|
| Multivariate relationship between pathogenic variants (dependent variable), mode of inheritance (independent variable), IQ (independent variable), facial dysmorphic features (independent variable) and psychiatric diagnosis (independent variable). | — |
Countries
Netherlands
Outcome results
None listed