chronische immuunziekten met vermoeidheids- en darmklachten chronic immune diseases
Conditions
Interventions
1. DJ Repair. This is a mixture of glutamine, zinc and N-acetyl-L-cystein
(NAC).
2. Eight fixed mixtures of probiotics, prepared by the manufacturer to achieve
predefined effects.
3. A mixture of w
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Age 18 years and above 2. Chronic immune disease, currently in remission/non-active 3. Significant fatigue, as measured by the Short Fatigue questionnaire 4. Persistent intestinal complaints, as measured by the IBS-SSS
Exclusion criteria
Exclusion criteria: 1. Changes of medication or diet in the previous 3 months or during the course of the study 2. Current exacerbation of chronic immune disease; 3. Excessive alcohol intake 4. History of drug abuse 5. Antibiotic use within 6 months prior to the study start 6. Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patient partly self-selected end points (up to 5) which they will choose to score on a daily basis in an app. Also symptoms of fatigue and gastro-intestinal complaints will be measured by validated questionnaires, respectively the Verkorte Vermoeidheidsvragenlijst (VVV, abbreviated fatigue questionnaire), CIS20, IBS-SSS and GI-symptoms questionnaire. Primarily for diagnoses and treatment reasons blood, saliva and fecal samples will be collected both at the start and after intervention, which will be also used for further mechanistic research. We will study if there are shifts in the microbiota composition and changes in inflammatory cytokine levels that will provide us with possible (non) responder- specific biomarker profiles. | — |
Secondary
| Measure | Time frame |
|---|---|
| See primary endpoints. | — |
Countries
Netherlands
Outcome results
None listed