Insulin Resistance Syndrome Metabolic Syndrome Syndrome X
Conditions
Interventions
At the end of the intervention and the control period, study measurements will
be performed during two test days. After an overnight fast, a one-step
hyperinsulinemic-euglycemic clamp with glucose t
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Aged between 50-70 years - Men and postmenopausal (two or more years after last menstruation) women - Waist circumference for men > 102 cm and for women > 88 cm (abdominally obese) - Impaired fasting glucose concentrations (between 5.6 - 7.0 mmol/L in accordance with the American Diabetes Association guidelines for prediabetes) at two screening visits - Fasting serum total cholesterol
Exclusion criteria
Exclusion criteria: - Current smoker, or smoking cessation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is the difference in muscle insulin sensitivity between the intervention and the control period. All measurements will be performed fasted. | — |
Secondary
| Measure | Time frame |
|---|---|
| A muscle biopsy will be taken to assess mitochondrial function. Vascular function and characteristics of muscle vasculature will be assessed during another test day. | — |
Countries
Netherlands
Outcome results
None listed