Aandoeningen van de bloeddrukregulatie Orthostatic hypotension
Conditions
Interventions
None listed
Sponsors
Radboud Universiteit Nijmegen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Age: between 70 and 90 years * Cognitive score as clinically assessed using Mini Mental State Examination (MMSE): > 21 points out of 30.
Exclusion criteria
Exclusion criteria: Patients with the following conditions preventing them from performing the test conditions will be excluded: * Body mass index (BMI) > 35 * Neurological diseases causing inability to walk unassisted * Musculoskeletal o immobilization for 1 week during the last 3 months o orthopedic surgery during the last 6 months * Muscle disorders causing leg muscle weakness * Any disorder causing chronic pain or pain during walking with pain score > 6 on scale from 1-10 * Severe vision problems, causing inability to walk unassisted * General o Acute infections affecting general condition o Recent hospitalization (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Baroreflex sensitivity and cerebral autoregulation in patients with symptoms, compared between those with and without OH - Baroreflex sensitivity and cerebral autoregulation in patients with OH, compared between those with and without symptoms - Collinearity between individual BRS, CAR and orthostatic BP drop magnitude measurements, separate for the three patient groups | — |
Secondary
| Measure | Time frame |
|---|---|
| - Accuracy of PPG based OH classification, separate for the three patient groups. - The Pearson correlation of PPG based BP estimation with the gold standard Finapres BP measurement between 0-30 seconds after standing up. - Patient reported convenience, using 1-10 scale. - The intraclass correlation coefficient of repeats of the same postural change in the same individual. | — |
Countries
Netherlands
Outcome results
None listed