colorectal cancer colorectal carcinoma
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Individuals participating in the Dutch national colorectal cancer screening program who: - Have a positive FIT (fecal immunohistochemical test), prior to sequential colonoscopy (performed in the Erasmus MC); - Grant informed consent to participate in this study;;Lynch Syndrome carriers under surveillance of gastroenterologists in the Erasmus MC, who: - Have proven Lynch syndrome (DNA mismatch repair mutation); - Are >=18 years; - Grant informed consent to participate in this study.
Exclusion criteria
Exclusion criteria: Individuals participating in the Dutch national colorectal cancer screening program who: - Are known to be carrier of a genetic predisposition for colorectal cancer (for example Familial Adenomatous Polyposis or MUTYH Associated Polyposis); - Have a negative FIT; - Have a positive FIT with sequential colonoscopy already performed; - Are unwilling to undergo colonoscopy or receive unexpected, but relevant and actionable findings; - Underwent a failed colonoscopy;;Lynch Syndrome carriers who: - Are unwilling to undergo colonoscopy or receive unexpected, but relevant and actionable findings; - are
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The agreement between cfDNA profiles and DNA profiles of corresponding lesions found during regular colonoscopy. | — |
Secondary
| Measure | Time frame |
|---|---|
| The extent of psychological burden caused by this screening tool. | — |
Countries
Netherlands
Outcome results
None listed