Post-traumatic stress disorder psychological trauma PTSD
Conditions
Interventions
None listed
Sponsors
Rijksuniversiteit Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Participants must be full of age (18 years or older). 2. Meet the criteria for post-traumatic stress disorder (PTSD). 3. Must be enrolled in trauma-focused psychotherapy (TFT). 4. Participants must be capable of giving consent.
Exclusion criteria
Exclusion criteria: 1. Presence of metallic devices, e.g. metal implants or cardiac pacemaker 2. Meet diagnostic criteria for a. Pain disorder b. Bipolar disorder c. Dissociative Identity Disorder d. Schizophrenia e. Neurological disorders 3. Alcohol or drug abuse in the last 6 months 4. Suspected pregnancy 5. Claustrophobia 6. Refusal that general practitioner will be informed when structural brain abnormalities could be detected during experiment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are differences in BOLD activation patterns between responders vs. non-responders following the fMRI paradigms. A treatment responder analysis will be conducted to identify (1) pre-post changes in brain activation responding to a script-driven trauma confrontation protocol and emotion reactivity task and (2) pre-therapy activation which could predict treatment outcome. Functional imaging data will be analyzed with region-of-interest and whole-brain exploratory analysis. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary parameters include 1) the psychophysiological reactivity elicited during the functional imaging paradigms (script driven imagery and emotion reactivity), 2) resting-state functional imaging data for connectivity analyses, and 3) patient characteristics to describe the patients and characterize possible subgroups of patients (those who will and those who will not benefit from treatment). | — |
Countries
Netherlands
Outcome results
None listed