Cardiorespiratory fitness in newly diagnosed patients with Relapsing Remitting Multiple Sclerosis compared to matched healthy controls: already lagging behind from the start?

Cardiorespiratory fitness in newly diagnosed patients with Relapsing Remitting Multiple Sclerosis compared to matched healthy controls: already lagging behind from the start? - VO2max in early MS / LOW2early

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON48103

Enrollment

Registered

2019-02-12

Start date

2019-10-17

Completion date

Unknown

Last updated

2025-02-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Sclerosis (MS)

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: MS patients In order to be eligible to participate in this study, the MS patients must meet all of the following criteria: - definite diagnosis of Relapsing Remitting MS according to the most recent international diagnostic criteria; - diagnosis within 12 months prior to inclusion date; - disease severity: EDSS score of maximal 2 with normal pyramidal and cerebellar functions (i.e. Functional Systems Score for pyramidal functions = 0 and Functional Systems Score for cerebellar functions = 0). - age at definite diagnosis between 18-65 years. Healthy Siblings/Controls (controls) In order to be eligible to participate in this study, the healthy controls must meet the following criteria: - healthy sibling of participant with MS, and matching with respect to sex, age (± 5 years), level of physical activity in the past year; - healthy persons, matching to MS participants with respect to sex, age (± 5 years), and level of physical activity in the past year. - age between 18-65 years

Exclusion criteria

Exclusion criteria: - Physician-confirmed diagnosis of (other) neurological disorders or systemic or malignant neoplastic diseases. - Serious comorbidities precluding Cardiopulmonary Exercise test (CPET) or Lung function examination. - Use of heart rate regulating medication (e.g. Beta-blockers). - Use of medication for lung diseases. - Being pregnant, or receiving medical help/fertility treatment to become pregnant. - Body Mass Index of 30 or higher. - Sports and exercise activities in the past year of > 10 hours/week. - Does not speak Dutch.

Design outcomes

Primary

Measure	Time frame
Maximal exercise capacity, lung function, and mitochondrial function of muscles.	—

Secondary

Measure	Time frame
Blood parameters: Haemoglobin concentration, hematocrit, C-reactive protein (CRP).	—

Countries

Netherlands

Outcome results