cognitieve en hersenveroudering
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: The Dutch famine birth cohort consists of around 2400 people who were born around the time of the Dutch famine. For the present study we will randomly select a subsample of 40 participants per study group (born before famine, exposed to famine during early, mid or late gestation and conceived after famine), in total 200 participants, starting with those who also particpated in a study we performed in 2012. Those wo are still alive, living in the Netherlands with known contact information are eligible for participation.
Exclusion criteria
Exclusion criteria: Cohort members who are unable to visit the clinica due to mental or physical illness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In a subsample of 200 cohort members, we will measure cognitive function by applying neuropsychological testing, brain parameters by means of a neuroimaging protocol. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters are DNA methylation differences . | — |
Countries
Netherlands
Outcome results
None listed