epilepsy seizure
Conditions
Interventions
None listed
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
2 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Patients have refractory epilepsy and are candidates for epilepsy surgery - We include adults (VUmc) or children of six years of age or older (UMCU). Adults: - Patients have already undergone a clinical SQUID-based MEG and dEEG at VUmc - 3 patients: confirmed focal source on dEEG of mesial temporal origin - 1 patient: frequent seizures (~daily);Children: - Six years of age or older - Patients have already undergone a clinical SQUID-based MEG with simultaneous scalp-EEG at VUmc - Confirmed focal source of epileptiform activity in clinical MEG or EEG
Exclusion criteria
Exclusion criteria: - Have already undergone surgery for their current epilepsy - The patients have already undergone a clinical SQUID-based MEG. Those patients who had claustrophobic or anxiety experiences from being enclosed in the magnetically shielded room will be excluded. - Patients with many artefacts, related to either movement or metal implants (not MEG compatible), on their clinical SQUID-based MEG
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome is a demonstration of the effectiveness of OPMs as a powerful diagnostic tool in epilepsy. The parameter we study is epileptiform activity (spikes, spike-waves). We will compare the even-rate (number of spikes/minute) and the strength (in terms of signal-to-noise ratio) between the different techniques. | — |
Secondary
| Measure | Time frame |
|---|---|
| Demonstration of the ability to successfully record MEG signals during a seizure. | — |
Countries
Netherlands
Outcome results
None listed