mond, keelholte dry mouth xerostomia
Conditions
Interventions
Local administration of pilocarpine (eye)drops orally in a low dose group or
a high dose for 14 days
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • >= 70 years of age;• Clinical diagnosis of chronic dry mouth defined as a Numeric Rating Scale (NRS) score >= 5 (scale 0 - 10, with 0 = no dry mouth and 10= worst possible dry mouth) on severity of xerostomia for more than 3 months.
Exclusion criteria
Exclusion criteria: • Existence of cognitive impairment and/or diagnosis of dementia appraised by treating physician ;• Inability to fill out the questionnaires due to other reasons;• Prior radiation therapy of the head-and-neck region;• Known m. Sjögren disease;• Contra-indications for parasympathicomimetics (uncontrolled asthma, acute heart failure, active peptic ulceration, known hypersensitivity to pilocarpine, and when miosis is undesirable, e.g., in acute iritis and in narrow-angle (angle closure) glaucoma.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| - Adverse effects - Other symptoms - Global perceived effect | — |
Primary
| Measure | Time frame |
|---|---|
| Change in xerostomia score Change in oral health-related quality of life | — |
Countries
Netherlands
Outcome results
None listed