The effect of changing CO2 levels on perioperative cerebral and microcirculatory hemodynamics in infants undergoing laparoscopic surgery

The effect of changing CO2 levels on perioperative cerebral and microcirculatory hemodynamics in infants undergoing laparoscopic surgery - The XXX monitoring Study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON48061

Enrollment

Registered

2019-08-28

Start date

2019-08-16

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diseases that require surgical correction through laparoscopic surgery

Interventions

None listed

Eligibility

Age

2 Years to 11 Years

Inclusion criteria

Inclusion criteria: Cardiovascular healthy children 0 to 1 year of age undergoing laparoscopic surgery

Exclusion criteria

Exclusion criteria: - Absence or refusal of parental informed consent; - Preterm new born (adjusted age * 36 weeks); - Cardiovascular, pulmonary, renal, oncological disease; - Genetic syndrome

Design outcomes

Primary

Measure	Time frame
- End tidal CO2 (etCO2, kPa); - Transcutaneous partial pressure CO2 (PCCO2, kPa); - Sublingual microcirculation: parameters of vessel density (total vessel density (TVD, mm/mm2) and perfused vessel density (PVD, mm/mm2)) and parameters of vascular perfusion (microvascular flow index (MFI), proportion of perfused vessels (PPV, %), red blood cell velocities (RBCV, mm/s) and heterogeneity index of flow (heterogeneity index (HI))); - Cerebral oxygenation: regional cerebral oxygen saturation (rScO2, %); - Cerebral perfusion: cerebral blood flow velocities (CBFV, cm/s) of the lateral striate artery and the medial cerebral artery; - Cerebral activity: neuronal electrical activity and background patterns over time.	—

Measure

Time frame

- End tidal CO2 (etCO2, kPa); - Transcutaneous partial pressure CO2 (PCCO2, kPa); - Sublingual microcirculation: parameters of vessel density (total vessel density (TVD, mm/mm2) and perfused vessel density (PVD, mm/mm2)) and parameters of vascular perfusion (microvascular flow index (MFI), proportion of perfused vessels (PPV, %), red blood cell velocities (RBCV, mm/s) and heterogeneity index of flow (heterogeneity index (HI))); - Cerebral oxygenation: regional cerebral oxygen saturation (rScO2, %); - Cerebral perfusion: cerebral blood flow velocities (CBFV, cm/s) of the lateral striate artery and the medial cerebral artery; - Cerebral activity: neuronal electrical activity and background patterns over time.

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Countries

Netherlands

Outcome results