skin cancer
Conditions
Interventions
Broad-band UV exposure of the back skin of the volunteers at sub-erythemal dose
of 20-30 mJ/cm2, 3 times weekly during 3 weeks. Before each UV-irradiation
samples urine and stratum corneum will be c
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Male individuals between 18 and 65 years. * Fitzpatrick skin types II or III. * Individuals free of any dermatological or systemic disorder which would interfere with the results, at the discretion of the investigator. * Individuals who have read, understood and signed an informed consent document relat-ing to the specific study to which they are subscribing. * Individuals with no known abnormal response to sunlight (e.g. polymorphic eruption).
Exclusion criteria
Exclusion criteria: * Individuals taking medication which in the opinion of the investigator would mask or in-terfere with the results. * Individuals with chronic skin allergies. * Individuals with abnormal reaction to the sun. * Subjects who used sun beds in the previous 30 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The levels of urocanic acid isomers, MMP, cytokines and DNA-photoproducts measured in the stratum corneum and/or urine at different time points during a 3-weeks study | — |
Secondary
| Measure | Time frame |
|---|---|
| The levels of urocanic acid isomers, MMP, cytokines and DNA-photoproducts at different stratum corneum depths (i.e. 1st to 12th collected tape from the same skin site) | — |
Countries
Netherlands
Outcome results
None listed