Glucose metabolism suger metabolism
Conditions
Interventions
Heat exposureby means of a water-perfused suit. Water temperature during heat
exposure will initially be set at 39*C and adjusted as the test subject's core
temperature changes. In the neutral condi
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: * Signed informed consent * Men and women * Caucasian / white western European * Aged 45-65 years at the start of the study * Body mass index (BMI) 27-35 kg/m2 * Stable dietary habits (no weight loss or gain of more than 5 kg in the past 3 months * Stable sedentary lifestyle (not more than 2 hours of sports per week) * Women after their menopause, meaning cessation of menses for at least 24 months) and only if they are not under hormonal treatment * Suitable veins for cannulation or repeated venapuncture * Generally healthy, no medication use that interferes with metabolism, no signs of active cardiovascular disease, liver or kidney malfunction. If volunteers need medication, it will be reviewed with the dependent physician on individual basis.
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: * Type 2 Diabetes * Men Haemoglobin 3kg in the past three months) * Participation in another biomedical study within 1 month prior to screening visit * Participants, who do not want to be informed about unexpected medical findings, or do not wish that their treating physician will be informed, cannot participate in this study * Blood donation three month prior to study and three month after finishing study * Alcohol consumption of >2 servings per day for men and >1 serving per day for women * Smoking in the past 6 months A medical doctor will judge participation eligibility based on the medical history questionnaire, medication use and fasting blood parameters. If the medical doctor advises that someone cannot participate, they will be excluded from enrolment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assess the effect of acute, passively administered whole-body heat exposure on * hepatic insulin sensitivity * whole-body substrate oxidation * plasma metabolites. | — |
Secondary
| Measure | Time frame |
|---|---|
| Assess the effect of acute, passively administered whole-body heat exposure on * measures of thermophysiology, * cardiovascular parameters * thermal perception (thermal sensation and comfort) | — |
Countries
Netherlands
Outcome results
None listed