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Serial arterial spin labeling perfusion MRI in acute ischemic stroke: detecting incomplete microvascular reperfusion.

Serial arterial spin labeling perfusion MRI in acute ischemic stroke: detecting incomplete microvascular reperfusion. - Supermicro

Status
Unknown
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON47938
Enrollment
20
Registered
2019-09-10
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute ischemic stroke

Interventions

None listed

Sponsors

Erasmus MC, Universitair Medisch Centrum Rotterdam
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: -A clinical diagnosis of acute ischemic stroke -Age 18 years or older -NIHSS >/=2 -Treated with intravenous tPA

Exclusion criteria

Exclusion criteria: -Any previous stroke or known neurological disorder associated with structural brain abnormalities -Any contra-indication for MRI (e.g. ferromagnetic implant(s), claustrophobia, pacemaker) -Clinical condition unsuited for repetitive MRI imaging or prolonged stay at the Radiology department. -Pre-stroke modified Rankin Scale score > 2 -Participation in stroke trials interfering with the current study

Design outcomes

Primary

MeasureTime frame
The primary outcome of this study is the delta Cerebral Blood Flow (CBF) and infarct volume between time points 0 and 60 minutes.—

Secondary

MeasureTime frame
Secondary outcomes are the changes in CBF and concordant infarct volume evolution over different time points early after treatment (+30, +90, +120, +240 minutes).—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)