Endometrium outside of the uterus
Conditions
Interventions
Atosiban 6,75 mg intravenously bolus, followed by 18 mg per hour continuous
infusion for 3 hours, followed by 6 mg per hour continuous infusion for 3 more
hours.
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Laparoscopic, MRI or ultrasound confirmed endometriosis - Dysmenorrhea with painscore >=5 during menstrual period or withdrawal bleeding - Age between 18 and 45 years old
Exclusion criteria
Exclusion criteria: - Inability to come to the hospital for the experiment - Suspicion on a (post)menopausal state - Continuous treatment with oral contraceptives or progestagens - Current use of GnRh antagonist - Current ovarian stimulation - Current breastfeeding - Labour or breastfeeding within the last 6 weeks - Diagnosis of chronic pelvic pain - Inability to give informed consent - Language barrier - Diabetes Mellitus, type I or II - Hypersensitivity to atosiban or mannitol - Use of systemic betamimetics - Use of calcium channel blockers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in pain score on a visual analog scale | — |
Secondary
| Measure | Time frame |
|---|---|
| Use of analgisics, experienced and observed side effects, oxytocin and prostaglandin serum levels before and after admission. | — |
Countries
Netherlands
Outcome results
None listed