venous thromboembolism
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - First, objectively confirmed, symptomatic, unprovoked symptomatic pulmonary embolism and/or distal or proximal deep vein thrombosis of the leg - Age 40 years or older - Written informed consent
Exclusion criteria
Exclusion criteria: - One or more of the following risk factors for veneuze trombo-embolie (VTE): - known malignant disease prior to VTE defined as a cancer diagnosis or cancer treatment within the past 5 years; - trauma or fracture of the leg, surgical procedures, general anesthesia, or immobilization greater than 3 days within previous 3 months; - previous unprovoked venous thromboembolism; - known hereditary or acquired thrombophilia; - current pregnancy or puerperium (up to 3 months postpartum); - current estrogen therapy. - Greater than 10 days after VTE diagnosis; - Inability for blood withdrawal at baseline; - Inability or refusal to provide written informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| An adjudicated diagnosis of solid or haematological cancer which is confirmed by histology or cytology, or is unequivocally diagnosed by either imaging or tumour markers. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Early-stage solid cancer, defined as stage I or II solid cancer according to the AJCC criteria. - Solid cancer - Hematological cancer - Solid cancer and lymphoma - Recurrent venous thromboembolism - Major bleeding - Clinically relevant non-major bleeding - All-cause mortality - Cancer-related mortality | — |
Countries
Netherlands
Outcome results
None listed