anxiety neurosis obsessive-compulsive disorder
Conditions
Interventions
clinical profiles
cognitive profiles
magnetic resonance imaging
obsessive-compulsive disorder
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1) OCD patients (n
Exclusion criteria
Exclusion criteria: 1) OCD patients: * Lifetime diagnosis of a psychotic disorder, bipolar disorder, anorexia nervosa (note: binge eating and bulimia in past is OK, if not last 12 months), Tourette disorder or autism spectrum disorder with IQ
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. clinical measures (on specific symptoms) 2. neurocognitive profiles (behaviour on neuropsychological tests) 3. neural correlates on regional brain volumes (e.g. cortical thickness, surface area), white matter integrity (e.g. fractional anisotrophy), and resting state network connectivity, using magnetic resonance imaging (MRI). | — |
Secondary
| Measure | Time frame |
|---|---|
| We will explore whether three factors (childhood trauma, socioeconomic status (SES), and religiosity) moderate the link between our neuroimaging signatures and clinical and cognitive profiles. We focus on childhood trauma and SES because of their known effects on brain structure in healthy people, and their potential to confound imaging data. | — |
Countries
Brazil, India, Netherlands, South Africa, United States of America
Outcome results
None listed