prematurity preterm birth preterm labour
Conditions
Interventions
Low dose aspirin (80mg) versus placebo, initiated from 8-16 week up to 36 weeks
of gestation.
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Women with a singleton pregnancy with a previous spontaneous preterm birth (in a singleton pregnancy), defined as birth at a gestational age between 22 and 37 weeks
Exclusion criteria
Exclusion criteria: Women with a history of indicated preterm births for maternal reasons such as preeclampsia or HELLP and for fetal reasons such as intra uterine growth restriction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measure will be premature delivery, defined as a GA | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes will be a composite poor neonatal outcome (including BPD, PVL > grade 1, IVH > grade 2, NEC, ROP, culture proven sepsis and perinatal death, number of days on ventilation support, days of admission on the NICU, convulsions, asphyxia, proven meningitis, pneumothorax and total days in hospital until 3 months corrected age. Furthermore preterm delivery | — |
Countries
Netherlands
Outcome results
None listed