veroudering, energiemetabolisme. Ageing
Conditions
Interventions
The subjects will receive at random the following products: 1) intervention
product containing the NAD+-precursors nicotinic acid, nicotinamide, and
tryptophan in a whey protein source
2) control product consisting of an amino
acid mix resembling the whey protein source devoid of tryptophan, nicotinic
acid and nicotinamide.
Elderly
Metabolism
Muscle
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Males and females - Age * 65 * 80 years; - BMI * 20 kg/m2 * 30 kg/m2; - Normal physical activity levels: maximum of 1 hour per week engagement in a structured exercise session; - 6-minute walking distance of 465 meters or less; - Subject should be in sufficient health to participate in the experiments, to be judged by the responsible physician based on the subject's medical history.
Exclusion criteria
Exclusion criteria: - Not meeting all inclusion criteria; - Smoking; - Excessive alcohol use and/or drug abuse; - Subjects with diabetes mellitus type 2; - Significant food allergies or intolerances concerning the study products; - Participation in another biomedical study within 1 month before the first study visit, possibly interfering with the study results; - Medication use known to hamper subject*s safety during the study procedures; - Subjects who use selective serotonin re-uptake inhibitors (SSRI), or selective norepinephrin re-uptake inhibitors (SNRI), or monoamino oxidase inhibitors (MAO-inhibitors), or clomipramine, or St. John*s wort (Hypericum perforatum); - Subjects with contra-indications for MRI; - Subjects who do not want to be informed about unexpected medical findings; - Subjects who do not want that their treating physician to be informed; - Co-morbidities to which the intervention or program the may pose as a complicating factor; - Inability to participate and/or complete the required measurements.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main outcome parameters relate to the anticipated differences in mitochondrial function and include ex vivo mitochondrial respiratory capacity, in vivo mitochondtrial capacity, resting- and exercising energy metabolism, and in vivo mitochondrial capacity. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Glucose tolerance; - Physical performance; - Intramuscular cellular lipid content; - Hepatic fat; - Physical activity; - Quality of life; - Markers of mitochondrial metabolism. - Blood metabolites and biomarkers. | — |
Countries
The Netherlands
Outcome results
None listed