The immunohistochemical characteristics of the obstructed human bladder

The immunohistochemical characteristics of the obstructed human bladder - Characteristics of the obstructed human bladder

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON47879

Enrollment

Registered

2014-09-15

Start date

2016-02-29

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

benign prostate enlargement urinary retention

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: -Males above 18 years old with benign prostate hyperplasia -Prostate volume of at least 60cc for which they undergo open prostatectomy according to Hryntschak

Exclusion criteria

Exclusion criteria: -Neurological voiding disorders; including diabetes mellitus (severe or uncontrolled, or diabetes with peripheral nerve involvement), spinal cord injury, multiple sclerosis. -Malignancy of the lower urinary tract, including prostate. -Proven interstitial cystitis or clinical symptoms of interstitial cystitis.

Design outcomes

Primary

Measure	Time frame
Primary objective: To investigate whether the immunohistochemical characteristics of the bladder wall are different in obstructed bladders showing detrusor overactivity (DO) compared to obstructed bladders without detrusor overactivity and bladder outlet obstruction (BOO) induced urinary retention	—

Secondary

Measure	Time frame
Secondary objective: -To describe the immunohistochemical characteristics of the bladder wall and urethra -To investigate possible microanatomical connections between nerves, ganglia and interstitial cells in the human bladder -To investigate the distribution of receptors involved in bladder-urethral interactions in relation to bladder outlet obstruction -Mapping of different structures and layers of the bladder during bladder outlet obstruction by using two-photon laser scanning microscopy (TPLSM)	—

Measure

Time frame

Secondary objective: -To describe the immunohistochemical characteristics of the bladder wall and urethra -To investigate possible microanatomical connections between nerves, ganglia and interstitial cells in the human bladder -To investigate the distribution of receptors involved in bladder-urethral interactions in relation to bladder outlet obstruction -Mapping of different structures and layers of the bladder during bladder outlet obstruction by using two-photon laser scanning microscopy (TPLSM)

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Countries

Netherlands

Outcome results