arteriosclerosis atherosclerotic plaque calcification in the vessel wall
Conditions
Interventions
Single dose administration of the study drug -18F-choline- a radiotracer for
PET imaging.
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Patients known with symptomatic carotid artery stenosis (who are planned in the clinical setting for a carotid endarterectomy or who are referred to conservative therapy); - Age 18 years or older (no maximum age); - Informed consent by signing informed consent form regarding this study.
Exclusion criteria
Exclusion criteria: - Dementia, pregnancy, nursing mothers; - Serious neurological deficits at symptomatic side (hemi paralysis, complete aphasia); - Severe heart failure NYHA III-I and severe pulmonary dysfunction; - Contra-indications for MRI, such as ferromagnetic implants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Positive correlation between 18F-choline uptake on PET and degree of intraplaque inflammation on histology. | — |
Secondary
| Measure | Time frame |
|---|---|
| -The correlation between 18F-choline uptake as assessed by PET-MRI, FDG PET-MRI parameters of plaque vulnerability; -The association between the degree of 18F-choline uptake on PET with the cardiovascular risk profile and history of patients. | — |
Countries
Netherlands
Outcome results
None listed