Malnutrition
Conditions
Interventions
Appetite
Malnutrition
Microbiota
Older adults
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Age 65 years and older; Mentally competent to agree with and participate in study; Living at home (non-institutionalized); Participant of the LASA-cohort (Longitudinal Aging Study Amsterdam).
Exclusion criteria
Exclusion criteria: Body-Mass Index of 30 and above; Active malignancy (with the exception of basal cell carcinoma); History of inflammatory bowel disease; Immune suppression (either medicinal or disease-related); Use of antibiotics three months prior to faecal and salivary sampling; Long-term admittance (more than 4 weeks) to hospital or long-term care facility in three months prior to faecal and salivary sampling; Clinical symptoms of acute gastro-enteritis in the two weeks prior to faecal and salivary sampling (i.e. vomiting, acute diarrhoea).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study parameter will be the intestinal microbial composition as determined by 16S RNA-sequencing of frozen faecal samples. | — |
Secondary
| Measure | Time frame |
|---|---|
| We will investigate the oral microbiota as determined by 16S RNA-sequencing of frozen, tongue swabs and salivary samples. We will further determine metabolic, endocrine and inflammatory biomarkers from faecal, salivary and blood samples to investigate the different pathways through which the microbiota influences its host. We will also study the differences in oral microbiota and the relationship with subjects* sense of taste and smell as these might also influence loss of appetite. | — |
Countries
The Netherlands
Outcome results
None listed