Hyperthermia Induced Synthetic Lethality in Tumour Biopsies from Women with Cervical Cancer

Hyperthermia Induced Synthetic Lethality in Tumour Biopsies from Women with Cervical Cancer - Hyperthermia in Cervical Cancer Biopsies

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON47845

Enrollment

200

Registered

2016-05-26

Start date

2017-12-07

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cervical cancer

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: * Adult women with cervical cancer (>18 years) * who will have an investigation under general anesthesia (or: under spinal anesthesia), * and who have given written informed consent for extra biopsies for research.

Exclusion criteria

Exclusion criteria: * Women * 18 years, * Or who will not have an investigation under general anesthesia for whatever reason, * Unwilling or unable to give written informed consent, either because of mental limitations or because of a language barrier.

Design outcomes

Primary

Measure	Time frame
Tumour specimens will be used for a variety of in vitro and in vivo to investigate synthetic lethality caused by hyperthermia plus targeted DNA-repair inhibitors, i.e. PARP1-inhibitors, in combination with radiotherapy and cisplatin. Several laboratory parameters for treatment response	—

Secondary

Measure	Time frame
=	—

Countries

Netherlands

Outcome results