The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment

The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment - ExCersion-VCI

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON47838

Enrollment

Registered

2015-05-04

Start date

2015-10-05

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vascular Cognitive Impairment / Cognitive complaints by problems in the supply of blood to the brain

Interventions

Participants are randomized into an aerobic exercise program or into a control condition. The aerobic exercise program aims to improve cardiorespiratory fitness. The program takes 14 weeks in total,

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients with vasculair cognitive impairment, age: 50-80yr, cognitive complaints, independency in daily life, clinical dementia rating 22, presence of a primary caregiver

Exclusion criteria

Exclusion criteria: Diagnosis of dementia; contra-indication for MRI; major neurological / psychiatric / cardiac or other medical disease that affects cognition and mobility

Design outcomes

Primary

Measure	Time frame
Change in cerebral perfusion, measured with arterial spin labeling (ASL) - MRI	—

Secondary

Measure	Time frame
Change in cognitive functions on neuropsychological testing; Change in cardiac function and structure (measured with parameters on cardiac MRI); Change in brain structure (measured with parameters on brain MRI); Change in physical fitness; Change in blood biomarkers; Change in neuropsychiatric measures and quality of life; Change in cerebral autoregulation and cerebral vasomotor reactivity;	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)