Analysis of food reward system and taste perception in cachexia induced by acute or chronic disease

Analysis of food reward system and taste perception in cachexia induced by acute or chronic disease - Food reward and taste perception in cachexia

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON47837

Enrollment

Registered

2015-12-30

Start date

2016-12-01

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anorexia Cachexia

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Head and Neck Cancer (HNC) patients treated with concurrent chemoradiation or bioradiation with curative intent. -Treatment completion 2-3 months ago -70>= age >=18;Healthy controls -Matched for age, gender, smoking behaviour, and scanning hour of the day.

Exclusion criteria

Exclusion criteria: For all groups: - Contra-indications for fMRI examination (operation to your head or brain in the past; implanted electronic devices, for instance a pacemaker, neurostimulator, cochlear or hearing implant; insulin pump under your skin; pregnant subjects, claustrophobia; pregnancy; metal parts in your body (except from teeth filling and connectors): implants; brain vessel clamps, prostheses, intra-uterine device, metal splinter in the eye, metal braces or other metal objects, permanent eye make-up) - Pregnancy - Psychiatric or other disorders likely to impact on informed consent - Presence of brain metastasis (screening is not mandatory) - Medical history of cerebrovascular accident, brain tumour, brain metastasis - Previous radiotherapy to brain, both stereotactic and whole brain radiotherapy - Memory problems - Current use of tube feeding or parental nutrition - Patients with an active second malignancy - Patients unable to lie still for 2 hours - Unable to complete the cognitive task in the imitation scanner - Allergy to gluten-, milk- or wheat products - Self-reported hyperthyroidism - Current use of appetite stimulant medications - Recurrent head and neck cancer (rHNC) - Previously administered systemic anti-tumor therapy - Reirradiation setting - Analphabetic - Mini mental state examination score

Design outcomes

Primary

Measure	Time frame
The main endpoint of this study is neural representations of taste stimuli.	—

Secondary

Measure	Time frame
Secondary endpoints are the relation between brain reward-related activity, anorexia based on a dietary questionnaire and in LAHNSCC patients only, the relation between taste perception and food reward related activity and degree of recovery after chemoradiation (CRT).	—

Countries

Netherlands

Outcome results