Sleep and cognition hypothesis in maritime pilots

Sleep and cognition hypothesis in maritime pilots - SCHIP

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON47817

Enrollment

Registered

2016-09-01

Start date

2016-11-23

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neurodegeneratieve ziekten Alzheimer's disease dementia

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Maritime pilots, -Written informed consent -Age 50-60 -Male -Subject is in good health as established by medical history -Medication free, Healthy volunteers -Written informed consent -Age 50-60 -Male -Finished HBO education -Subject is in good health as established by medical history -Medication free -Normal sleep behavior, Pittsburg Sleep Quality Index score of

Exclusion criteria

Exclusion criteria: -Self reported difficulty in sleeping in unfamiliar environment -Use of sedative-hypnotic medication -Abnormal movement of the non-dominant arm -Inability to understand Dutch - Subjects with contra indications for PET-CT and/or MRl, e.g. due to claustrophobia, metal in upper body, have an implant or who suffer from epilepsy. Subjects who are currently participating in another study or have participated in a clinical study within 30 days, based on their own report about participation history -Subjects with a history of drug or alcohol abuse -Subjects who are part of the study staff personnel or family members of the study staff personnel -Neurological disorder (stroke, dementia, epilepsy, brain trauma) -Subjects who wish not to be informed of accidental findings in the PET-CT and/or MRI part of this study.

Design outcomes

Primary

Measure	Time frame
Amount of SWS during one night of polysomnography, total score on cognitive testing	—

Secondary

Measure	Time frame
- Difference in duration of SWS between maritime pilots and controls (PSG); - Brain amyloid load in maritime pilots (compared to normative population-based values); - Cortical and hippocampal atrophy in maritime pilots; - DMN activity in maritime pilots; - Cognitive effort trade-off in maritime pilots; - Functional and structural connectivity in maritime pilots; - Presence of small vessel disease (SVD) in maritime pilots; - Cerebral blood flow in maritime pilots.	—

Measure

Time frame

- Difference in duration of SWS between maritime pilots and controls (PSG); - Brain amyloid load in maritime pilots (compared to normative population-based values); - Cortical and hippocampal atrophy in maritime pilots; - DMN activity in maritime pilots; - Cognitive effort trade-off in maritime pilots; - Functional and structural connectivity in maritime pilots; - Presence of small vessel disease (SVD) in maritime pilots; - Cerebral blood flow in maritime pilots.

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Countries

Netherlands

Outcome results