Cardiac mitochondrial function; Comparison of in and ex vivo measurements

Cardiac mitochondrial function; Comparison of in and ex vivo measurements - 31P-MRS study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON47816

Enrollment

Registered

2015-04-15

Start date

2017-03-21

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diabetic cardiomyopathy

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Patients undergoing elective valve replacement or cardiopulmonal bypass surgery - Gender: male or male - The patients should be aged 40-75 years - The type 2 diabetic patients should be obese (BMI > 27 kg/m2) and non-insulin dependent - The obese controls should be BMI matched with the diabetic patients (BMI > 27 kg/m2) - The lean subjects should have a normal BMI (20-25 kg/m2)

Exclusion criteria

Exclusion criteria: - Insulin dependent diabetic subjects. - Patients with instable angina or heamodynamically instable patients - Use of Thiazolidines (glitazone/rosiglitazone/pioglitazone/troglitazone) - Weight gain/loss > 3 kg in the last 6 months or signs of cachexia - Contraindications for MRI scans.

Design outcomes

Primary

Measure	Time frame
The primary goal is to compare in vivo with ex vivo measurements of mitochondrial function through regression analysis.	—

Secondary

Measure	Time frame
Furthermore markers of PPAR-expression will be examined and statistical analysis will be done to assess differences between groups (diabetic/lean/obese) where P	—

Countries

Netherlands

Outcome results