Parkinson's Disease
Conditions
Interventions
Sponsors
Universiteit van Amsterdam
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Age between 18 and 80 years old Clinical diagnosis of Parkinson's disease based on self-reporting by the patient Patients must be able to walk into the scanner room and climb onto the scanner bed Current treatment with anti-Parkinson medication Patients must meet the requirements to safely undergo MRI scanning, as determined using an MR-checklist, and a short interview Signed informed consent
Exclusion criteria
Exclusion criteria: A history of concomitant psychiatric or neurological disease, other than Parksinson's disease as well as a history of stroke or traumatic brain injury, as assessed by self reports Claustrophobia Implanted ferromagnetic particles Any contra-indication for MRI research, as assessed by an MRI-checklist
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Obtained MRI data will be used to develop a probabilistic subcortical 7T atlas of a PD population. We will measure signal to noise ratio, Dice coefficients, Center of Gravity measurements, susceptibility values, and connectivity in multiple subcortical brain structures. To validate and quantify the advantage of using 7T over 3T scans, we will compare 7T and 3T results in the first year. | — |
Secondary
| Measure | Time frame |
|---|---|
| N.A. | — |
Countries
The Netherlands
Outcome results
None listed