atrial fibrillation heart rhythm disturbances
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - On-pump surgery - Elective sternotomy for coronary artery bypass grafting or mitral valve surgery or aorta- or aortic valve surgery - CHADS VASC score >= 2 - Sinusrhythm - Age between 18 and 80 years
Exclusion criteria
Exclusion criteria: - Documented or reported history atrial fibrillation, atrial flutter (duration > 5 minutes) or ventricular tachycardia. - Emergency or redo of CABG or valvular surgery - Endocarditis, pericarditis - Active systemic inflammation - active malignancy - NYHA class IV heart failure symptoms - Left ventricular ejection fracton
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study parameters are tissue miRNAs, atrial histopathology and blood biomarkers. Blood biomarkers will include miRNAs and markers of inflammation, oxidative stress, markers of fibrosis formation and circulating microRNAs. These will be correlated to the incidence of post-operative AF and the incidence of newly developed AF after 24 months follow-up. The study will be extended to five years. | — |
Secondary
| Measure | Time frame |
|---|---|
| Additional study parameters on the process of atrial remodeling and clinical data will be collected and include: - Cardiac imaging data - Clinical data on cardiac history - Assessment of stroke-free status - Epicardial mapping during thoracic surgery - Experienced health | — |
Countries
Netherlands
Outcome results
None listed