Anxiety Stress
Conditions
Interventions
Subjects will be administered 200 mg of nutritional supplement L-theanine 30
minutes before start of the test battery. This dosage is in line with previous
research. The product will be obtained fro
Sponsors
Universiteit Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must the following criteria:;- Subject is a legally competent adult, aged 18 years and older - Subject agrees to participate in the study by giving written informed consent.
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study:;- Subject is currently taking (prescribed or non-prescribed) psychoactive medication - Subject is mentally incapacitated, has significant emotional problems at the time of the study, or has a history of any significant psychiatric disorder (as per self-report). - Subject has a history of any cardiac disorder or neurological disease. - Reduced startle reactivity, defined as no discernible response in at least 3 out of the 12 startle stimuli. - Female subjects who may be pregnant or unwilling to commit to using reliable contraception at the time of the study. -Subject fails to comply with study procedures (e.g., drank a caffeinated beverage shortly before the test)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Study 1 and 2: Fear-potentiated startle, defined as the increase in startle reflex magnitude evoked during the threat state as opposed to startle reflex magnitude during the safe state. The STAI state is used to assess the anxiety induced by the elements of the test battery. | — |
Secondary
| Measure | Time frame |
|---|---|
| Study 1: Increases in skin conductance, salivary alpha amylase, blood pressure and heart rate during FPS, Trier, Stroop, Lorist and Higashiyama tasks. Performance on Trier, Stroop, Lorist and Higashiyama tasks. EEG alpha band power. For study 2 (amendment on 11-02-2019) the research is repeated with only one secondary parameter: EEG alpha band power. | — |
Countries
Netherlands
Outcome results
None listed