Compulsivity in gambling disorder and obsessive-compulsive disorder: a functional magnetic resonance imaging (fMRI) study

Compulsivity in gambling disorder and obsessive-compulsive disorder: a functional magnetic resonance imaging (fMRI) study - Compulsivity in gambling and OCD

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON47769

Enrollment

Registered

2017-02-17

Start date

2017-02-22

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gokverslaving gambling disorder obessive compulsive disorders repetitive behaviour

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Inclusion process: Potential participants are informed about the study and receive an information letter. After this, they are contacted by telephone. If interested to participate, screening for inclusion and exclusion criteria is performed, using structured diagnostic interviews, e.g. Composite International Diagnostic Interview (World Health Organisation, 1997). OCD group: * DSM-5 diagnosis of OCD * No other psychiatric disorder * Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) score cut-off of 20 * 18-65 years of age * Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements ;GD group: * DSM- 5 diagnosis for Gambling Disorder * No other psychiatric disorders. * Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements * 18-65 years of age ;HC group: * No current psychiatric diagnosis no history of OCD or GD. * Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements * 18-65 years of age

Exclusion criteria

Exclusion criteria: All groups: * Current major depressive disorder, bipolar disorder, psychotic disorder, alcohol or substance dependence, or any cognitive disorder as assessed with the MINI neurological disorders section * IQ below 80 * insufficient command of the Dutch language * MRI contraindications such as metal implants, claustrophobia, pregnancy * recent (

Design outcomes

Primary

Measure	Time frame
Comparing patients with compulsive disorders (GD + OCD) with heathy controls to assess pathological processes. Comparing GD patients and OCD patients to test similarities and differences in: 1) The relationship between preferences of risky and ambiguous behavior, confidence and compulsive behavior. 2) Confidence coding in VMPFC. 3) The effect of negative outcome anticipation on compulsive behavior and associated brain regions.	—

Measure

Time frame

Comparing patients with compulsive disorders (GD + OCD) with heathy controls to assess pathological processes. Comparing GD patients and OCD patients to test similarities and differences in: 1) The relationship between preferences of risky and ambiguous behavior, confidence and compulsive behavior. 2) Confidence coding in VMPFC. 3) The effect of negative outcome anticipation on compulsive behavior and associated brain regions.

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Secondary

Measure	Time frame
* Functional connectivity as measured with fMRI during the resting-state condition * Self-reports of development and experience of compulsions.	—

Countries

Netherlands

Outcome results