Parkinsons's disease symptoms of depression
Conditions
Interventions
Depressive symptoms
Emotions
Light
Parkinson
Sponsors
VU Medisch Centrum, Amsterdam UMC
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Depression: - Age > 40 years - Significant symptoms of depression (score > 13 on the Inventory of Depressive Symptomatology (IDS-SR))40 - Symptomatic on the depression part of the Composite International Diagnostic Interview * Short Form (CIDI-SF)41 - Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements.;PD: - Age > 40 years - Idiopathic PD, as diagnosed by the UK Brain Bank Criteria - Mild PD stage 1-3, based on Hoehn & Yahr scale - Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements - MMSE 24;Control: - Age > 40 years - Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements.
Exclusion criteria
Exclusion criteria: PD - Early onset PD ( 13 on the IDS-SR) - Symptomatic on the CIDI-SF.;All groups - Current diagnosis of bipolar disorder, psychotic disorder, alcohol or substance dependence, or any cognitive disorder - Neurological disease (other than PD for the PD group) stroke or major head trauma, current or in history - MRI contraindications such as metal implants, claustrophobia, left-handedness, pregnancy - Self-reported inability or unease to cease smoking for 24 hours prior to testing - Current treatment with tricyclic antidepressant or antipsychotic medication - Ophthalmic disorder, color blindness, severe visual impairment or auditory impairment - Travel to a different time zone within the last month - Night work or rotating shift work.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Our main study endpoints include 1) Blood Oxygenation Level Dependent Signal (BOLD) in people with PD and persons with symptoms of depression compared with controls | — |
Secondary
| Measure | Time frame |
|---|---|
| 2) PD and depressive symptoms and their correlation to brain sensitivity to light; 3) Anatomical connectivity as measured with diffusion tensor imaging (DTI); 4) Daily subjective mood and its correlation to 24-hour ambient light exposure patterns and body temperature rhythm, the sleep wake cycle and brain sensitivity to light. | — |
Countries
The Netherlands
Outcome results
None listed