asthma chronic airway inflammation
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
2 Years to 17 Years
Inclusion criteria
Inclusion criteria: General: - Between 6-18 years of age - Doctor diagnosis of asthma;In addition to the general criteria, a case with uncontrolled asthma (case group A) should meet: - Asthma treatment Global INitiative of Asthma (GINA) step 3 or higher - * 1of the following criteria (based on the guideline *Childhood Asthma* of the section paediatric pulmonology of the Dutch Society of Pediatricians, 2007): - Frequent exacerbations requiring OCS use (*1 in the past year) and/or - Severe exacerbations requiring hospitalization or ER visits in the past year and/or - ACQ/ACT scores indicating uncontrolled asthma ;In addition to the general criteria, a case with an acute exacerbation (case group B) should meet: - Asthma treatment Global INitiative of Asthma (GINA) step 2 or higher - Current severe asthma exacerbation requiring hospitalization ;In addition to the general inclusion criteria, a control should meet the following criteria: - Asthma treatment Global INitiative of Asthma (GINA) step 3 or higher - Lack of severe exacerbations requiring OCS use or hospitalizations or ER visits in the past year
Exclusion criteria
Exclusion criteria: - Recent use of a course of antibiotics (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in biomarker profiles (breathomics, microbiomics, metabolomics, epigenomics and [pharmaco]genomics), between children responding to treatment and children not responding to treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| We will compare the biomarkers profiles of cases during an exacerbation and controls, as well as the profiles within subjects (during and after exacerbation). Construction of the -omics algorithm to predict ICS response | — |
Countries
Netherlands
Outcome results
None listed