Medical assessment of adverse health outcomes in Dutch childhood cancer survivors; a nationwide project; DCOG LATER Q2008 onderzoek: Bone mineral density and body composition in survivors of childhood cancer

Medical assessment of adverse health outcomes in Dutch childhood cancer survivors; a nationwide project; DCOG LATER Q2008 onderzoek: Bone mineral density and body composition in survivors of childhood cancer - DCOG LATER Q2008 - bone

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON47723

Enrollment

2500

Registered

2015-01-23

Start date

2016-05-04

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

botten, bewegingsapparaat en fitheid impaired fitness and motor impairment osteonecrosis osteoposoris

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: All patients who were treated for childhood cancer (before age 18) in one of the Pediatric Oncology Centers between 1960 and 2001 and who survived for at least 5 years after diagnosis will be included in the DCOG LATER study. Participating centres are located in Amsterdam (VU University Medical Center (VUMC)), Groningen (Children's Cancer Center/ University Medical Center Groningen (UMCG)), Rotterdam (Rotterdam Erasmus MC-Sophia (REMC-S), Nijmegen (University Medical Center Nijmegen (UMCN)), Leiden (Leiden University Medical Center (LUMC) and Utrecht (Princess Máxima Center for Pediatric Oncology (PMC)). From this cohort, 2500 childhood cancer survivors will be asked to participate in this study. (BMI will be assessed in all 7000 survivors as regular patient care).

Exclusion criteria

Exclusion criteria: diagnosis of childhood cancer with survival less than 5 years, age at diagnosis >17 years or diagnosis while residing in foreign country, no cardiologic impairment(fitness)

Design outcomes

Primary

Measure	Time frame
1- Prevalence and exogenous and genetic risk factors of osteopenia and osteoporosis and subsequent fractures, per persons years in CCS. 2- Prevalence of over- and underweight as expressed by BMI and LBM. 3- Treatment and diagnosis related risk factors for irreversible osteonecrosis. 4- Treatment and diagnosis related risk factors for impaired motor function and muscle strength	—

Secondary

Measure	Time frame
N.A.	—

Countries

Netherlands

Outcome results