Central pain location in SCN9A-associated SFN: an fMRI pilot study.

Central pain location in SCN9A-associated SFN: an fMRI pilot study. - fMRI in small fiber neuropathy

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON47720

Enrollment

Registered

2015-11-02

Start date

2018-05-29

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

small fiber neuropathyhttps://www.toetsingonline.nl/to/ccmo_monitor.nsf/allabrs/53441-06?EditDocument#

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patient group (SCN9A-associated SFN) (n

Exclusion criteria

Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: a. Major depression according to DSM-V criteria or a history of major psychiatric disease. b. (History with) alcohol abuse c. Hospital Anxiety and Depression Scale (HADS) * 14 d. Subjects who have another pain syndrome than small fiber neuropathy. e. Contraindications for undergoing MRI: pacemaker, metallic foreign body (including aneurysm clip in the brain), claustrophobia, pregnancy, neurostimulator, pacemaker or other kinds of implanted devices or insulin pump. In case of cardiac valve replacement of ossicular replacement prosthesis the radiologist will be consulted.

Design outcomes

Primary

Measure	Time frame
Concerning the fMRI, change of connectivity in the central executive network (CEN) and sensorimotor network (SMN) is the primary endpoint. Change in brain connectivity have been observed in several neuropathic pain conditions affecting mainly the networks mentioned above: SMN tend to show hyperconnectivity while CEN hipoconnectivity. Concerning DTI, the study parameters are fractional anisotropy (FA) and axial diffusivity (AD).	—

Measure

Time frame

Concerning the fMRI, change of connectivity in the central executive network (CEN) and sensorimotor network (SMN) is the primary endpoint. Change in brain connectivity have been observed in several neuropathic pain conditions affecting mainly the networks mentioned above: SMN tend to show hyperconnectivity while CEN hipoconnectivity. Concerning DTI, the study parameters are fractional anisotropy (FA) and axial diffusivity (AD).

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Countries

Netherlands

Outcome results