Genetics and psychopathology in the 22q11.2 deletion syndrome: A follow up study

Genetics and psychopathology in the 22q11.2 deletion syndrome: A follow up study - Genes and psychopathology in 22q11DS: A follow up study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON47713

Enrollment

400

Registered

2009-05-12

Start date

2002-02-03

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Autisme en taalstoornissen Psychosis Schizophrenia

Interventions

None listed

Eligibility

Age

12 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Confirmed 22q11.2 deletion - Age range from 13th - 25th year of life (T1) and for the DNA study in parents: - biological parents of a youth with a confirmed 22q11.2 deletion

Exclusion criteria

Exclusion criteria: For the psychiatric and genetic studies there are no exclusion criteria.;Exclusion criteria for the Imaging studies: - Verbal IQ

Design outcomes

Primary

Measure	Time frame
- schizophrenia development - diagnosis of autistic spectrum disorder and/or language disorder - neurocognitive abilities, including intelligence and the longitudinal course thereof - proline concentration in the blood - DNA polymorphisms and RNA expression profile - Parent of origin - structural and functional characteristics of the brain obtained with MRI scanning	—

Countries

Netherlands

Outcome results