Cardiac muscle disease cardiomyopathy
Conditions
Interventions
energy metabolism
fibrosis
myocardium
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: (a) Patients with severe aortic valve stenosis who have a clinical indication for surgical aortic valve replacement according to the ESC guidelines, have been accepted for surgery, and have been placed on the waiting list (n=30). (b) Patients with hypertrophic cardiomyopathy and left ventricular outflow tract obstruction who have a clinical indication for surgical septal myectomy according to the ESC guidelines, have been accepted for surgery, and have been placed on the waiting list (n=20).
Exclusion criteria
Exclusion criteria: 1. Under the age of 18. 2. Renal failure (estimated glomerular filtration rate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are: 1. Pre-contrast and post-contrast T1 times as quantified by a MOLLI sequence. Extracellular matrix volume fraction as calculated from myocardial and blood pool pre-contrast and post-contrast T1 and haematocrit. 2. Myocardial creatine content based on 1H-MRS, relative to the total water signal. 3. Myocardial TG content based on 1H-MRS, relative to the total water signal 4. Histological quantification of collagen volume fraction in myocardial biopsies 5. Biochemical quantification of myocardial creatine and triglyceride content. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Standard cardiac parameters obtained during a routine cardiac MRI protocol, including left and right ventricular end-diastolic and end-systolic volumes, stroke volumes, ejection fractions, left ventricular wall thickness and mass. 2. Routine measurements of plasma glucose, insulin, HbA1c, cholesterol, and lipids will be obtained from blood samples obtained at the time of MRI. 3. MicroRNA levels as measured in myocardial tissue and peripheral blood. | — |
Countries
The Netherlands
Outcome results
None listed