convulsion epilepsy
Conditions
Interventions
The first seizure patients will undergo one paired pulse TMS session (selection
of 30 patients will undergo two TMS sessions) and thirty healthy controls will
undergo two paired pulse TMS sessions,
Sponsors
Universiteit Twente
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1) Patients presenting with a first (epileptic) seizure * Presentation of a first (epileptic) seizure * Ability to understand and comply with the instructions for the TMS session , 2) Healthy controls * Ability to understand and comply with the instructions for the TMS session
Exclusion criteria
Exclusion criteria: * Younger than 18 years * Contra-indications of TMS (although not absolute): (possibility of) pregnancy, metal objects in brain/skull, cochlear implant, deep brain stimulator, history of spinal cord surgery, drains in the spinal cord or ventricles, use of seizure threshold lowering or enhancing medication * Follow-up impossible due to logistical reasons, In addition, healthy subjects are excluded if they have a personal history of epilepsy or if they have a lesion in the brain, be it vascular, traumatic, infectious or metabolic.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary study parameters are the characteristics of the MEP (resting motor threshold (rMT) and long intracortical inhibition (LICI)) and TEP (amplitude and latency of peaks). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters include additional signal analysis methods applied on the MEP and TEP. For example, wavelet analysis of early and late TEPs and the spatio-temporal characteristics of the TEP. Other study parameters which are documented include: age, gender, handedness, seizure history, type of epilepsy; generalized or focal (if diagnosis epilepsy is confirmed afterwards), EEG abnormalities (if applicable) and MRI abnormalities (if applicable). | — |
Countries
Netherlands
Outcome results
None listed