Observational cohort study to assess the association between mitochondrial function and recovery after a primary total knee arthroplasty in the elderly.

Observational cohort study to assess the association between mitochondrial function and recovery after a primary total knee arthroplasty in the elderly. - Mitochondrial function and recovery

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON47672

Enrollment

Registered

2017-11-02

Start date

2018-02-19

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

joint wear Muscle weakness

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. Male or female of 60 years of age or older. 2. Indication for an unilateral, primary total knee arthroplasty, due to moderate to severe osteoarthritis of the knee joint (grade 3 * 4 on the Kellgren and Lawrence scale). 3. Formerly able to walk independently. 4. Signed informed consent prior to any study-mandated procedure. 5. Willingness to perform the at home measurements (Withings Body and Theripear). 6. Able to use a smart phone (iPhone or similar).

Exclusion criteria

Exclusion criteria: 1. History of a performed arthroplasty of the lower extremities within 12 months before study enrollment and having planned any arthroplasty of the lower extremities within 12 months after study enrollment. 2. History (within 3 months before screening) of alcohol consumption exceeding 2 standard drinks per day on average (1 standard drink = 10 grams of alcohol). 3. Concomitant disease or condition that could interfere with, or for which the treatment of might interfere with, the conduct of the study, or that would, in the opinion of the Investigator, pose an unacceptable risk to the subject in this study. 4. Underlying chronic disease, which, in the opinion of the investigator would interfere with study participation or the validity of the measurements.

Design outcomes

Primary

Measure	Time frame
- Total score on the KOOS questionnaire	—

Secondary

Measure	Time frame
- Time in seconds to complete the TUG test - Daily activity (in steps per day), measured continuous with Withings smartwatch - Skeletal muscle mass (in kg/m2), measured weekly by Withings Body smart scale - Quadriceps strength (in kg), measured by the CITEC hand-held dynamometer - Maximal grip strength (in kg), measured by the Jamar dynamometer - Maximal grip strength (in kg), measured at home by the Theripear	—

Measure

Time frame

- Time in seconds to complete the TUG test - Daily activity (in steps per day), measured continuous with Withings smartwatch - Skeletal muscle mass (in kg/m2), measured weekly by Withings Body smart scale - Quadriceps strength (in kg), measured by the CITEC hand-held dynamometer - Maximal grip strength (in kg), measured by the Jamar dynamometer - Maximal grip strength (in kg), measured at home by the Theripear

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Countries

Netherlands

Outcome results