malabsorption disorders metabolic diseases various epithelial disorders
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
2 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients that need to undergo biopsy or resection of gastrointestinal tract and/or liver. These include patients with suspected coeliakie, IBD, liver, oesophagus or stomach problems. We will include patients that undergo endoscopy for other reasons (like IBS or screening for cancer) as controls.
Exclusion criteria
Exclusion criteria: Patients using anticoagulantia or patients with easily bleeding mucosa, like in haemophylia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Analyse developmental and functional properties of epithelial stem cells isolated from gastrointestinal tract or liver to elucidate the role of human gastrointestinal stem cells both in normal homeostasis and epithelial disorders. | — |
Secondary
| Measure | Time frame |
|---|---|
| Develop methods to generate intestinal tissue from both children and adults for transplantation purposes. | — |
Countries
Netherlands
Outcome results
None listed