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Brain activation in fecal storage, defecation and fecal incontinence: a 1,5T fMRI pilot study in healthy volunteers

Brain activation in fecal storage, defecation and fecal incontinence: a 1,5T fMRI pilot study in healthy volunteers - Brain activation in fecal storage and defecation: a 1.5T fMRI pilot study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON47587
Enrollment
10
Registered
2016-05-09
Start date
2018-06-26
Completion date
Unknown
Last updated
2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

fecal incontinence

Interventions

None listed

Sponsors

Medisch Universitair Ziekenhuis Maastricht
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - age: 20-70 years - both males and females - fecal continent - able to understand and signed informed consent

Exclusion criteria

Exclusion criteria: - Use of pain medication and/or medication known to influence the gastro-intestinal tract - Neurological illnesses, affecting the central nervous system and/or brain - Psychiatric illnesses: i.e. claustrophobia, schizofrenia - Inflammatory bowel disease: Crohn*s disease, colitis ulcerosa - History of constipation, fecal incontinence or colorectal cancer - Anal fissures/fistula - The use of anti-depressives, anti-epileptics, sleep medication, morphine *like medication - Narcotic/alcohol abuse - Kidney failure - Pregnancy - Any medical implant (except those that are MR safe or MR conditional) - Retained wires to the body (e.g. temporary pacing); - Susceptible to cardiac collapse - Increased risk of heart attack or other cardiac problems - Cardiac arrhythmias; - Impaired thermoregulation; - Morbidly obese; - Nauseated (aspiration risk)

Design outcomes

Primary

MeasureTime frame
To objectify the BOLD-signal intensity in healthy volunteers during rectal filling and induction of fecal urgency using ballon distention.

Secondary

MeasureTime frame
n.a.

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)