Heart failure with preserved ejection fraction (HFpEF), perfusion and metabolism

Heart failure with preserved ejection fraction (HFpEF), perfusion and metabolism - Heart failure with preserved ejection fraction, early diagnosis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON47584

Enrollment

Registered

2016-11-24

Start date

2017-06-28

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

analysis of the disease Heart failure imaging

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. All patients * Age > 50 * Estimated glomerular filtration reserve (eGFR) >30 ml/min * Body weight30 ml/min 1.2 Hypertensive control patients;*No coronary artery disease (CAD; coronary stenosis>70% or history of CABG) *No heart failure *Estimated glomerular filtration rate (eGFR) > 30 ml/min *Preserved left ventricular ejection fraction (LVEF) (>140/90 mmHg or use of anti-hypertensive therapy *Normal cardiac structure and function on echocardiography

Exclusion criteria

Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study:;- Age

Design outcomes

Primary

Measure	Time frame
-Impaired perfusion (assessed using CMR): myocardial perfusion reserve	—

Secondary

Measure	Time frame
-Impaired peripheral muscle metabolism (assessed using MR spectroscopy): PCr/ATP ratio -Endothelial dysfunction (1) glycocalyx thickness (2) Heat-induced hyperaemic response -Level of fibrosis: T1 mapping on CMR -Biomarkers of endothelial dysfunction, oxidative stress, fibrosis and inflammation	—

Countries

Netherlands

Outcome results