Hypertriglyceridaemia too much lipids in the bloodstream
Conditions
Interventions
Test subjects will be exposed to cold during the second and third meal test.
During this cold exposure the point of shivering is reached, to maximize the
non-shvering thermogenesis and stimulate bro
Brown adipose tissue
Cold exposure
Post-prandial metabolism
Triglycerides
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Signed informed consent - Caucasian - Aged 20-50 years at the start of the study - Body mass index (BMI) 20-30 kg/m2 - Stable dietary habits (no weight loss or gain of more than 5 kg in the past 3 months - Stable sedentary lifestyle (not more than 2 hours of sports per week)
Exclusion criteria
Exclusion criteria: - Use of cholesterol or lipid-lowering medication - Active diseases (cardiovascular, diabetes mellitus, liver, kidney, cancer or other) - Participation in earlier research that included PET/CT scanning for detection of brown adipose tissue activity in the last 3 months - Alcohol consumption of >2 servings per day - Smoking in the past 6 months - Haemoglobine content
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Meal test: post-prandial metabolism of triglycerides, cholesterol and lipoprotein. PET/CT: Presence and activity of brown adipose tissue, as measured by PET/CT scan Muscle biopsy: cell culture, the role of skeletal muscle on the post-prandial clearance of triglcyerides Energy expenditure: measured by indirect calorimetry | — |
Secondary
| Measure | Time frame |
|---|---|
| Skin temperature: measured via iButtons on different places on the skin Core temperature: measured via a sensor in the gastro-intestinal tract | — |
Countries
The Netherlands
Outcome results
None listed