Zoom@SVDs: Zooming in at microvascular malfunction in Small Vessel Diseases with 7T MRI

Zoom@SVDs: Zooming in at microvascular malfunction in Small Vessel Diseases with 7T MRI - Zoom@SVDs

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON47570

Enrollment

Registered

2016-10-05

Start date

2017-03-20

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cerebral small vessel disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: participants must meet all of the following criteria: -For the patients only: symptomatic SVD defined as history of clinical lacunar stroke or cognitive impairment due to SVD -age over 18 -ability to provide informed consent

Exclusion criteria

Exclusion criteria: -Other major neurological or psychiatric conditions affecting the brain and interfering with the study design (e.g. multiple sclerosis, epilepsy, Parkinson*s disease) -For the controls only: history of symptomatic SVD or pronounced silent SVD on MRI -Contraindications for MRI

Design outcomes

Primary

Measure	Time frame
Measures of microvascular function at 7T MRI: - Difference in mean velocity and pulsatility index of perforator flow between patients with SVDs and healthy controls. - Difference in time course of the BOLD-fMRI signal to a visual stimulus in different cortical layers between patients with SVDs and healthy controls. - Difference in Cerebrovascular reactivity (CVR) to a hypercapnic stimulus between patients with SVDs and healthy controls.	—

Measure

Time frame

Measures of microvascular function at 7T MRI: - Difference in mean velocity and pulsatility index of perforator flow between patients with SVDs and healthy controls. - Difference in time course of the BOLD-fMRI signal to a visual stimulus in different cortical layers between patients with SVDs and healthy controls. - Difference in Cerebrovascular reactivity (CVR) to a hypercapnic stimulus between patients with SVDs and healthy controls.

—

Secondary

Measure	Time frame
Relationship between measures of microvascular function at 7T MRI and: - Severity (total burden) and location of conventional markers of SVD on 3T MRI at baseline and progression of these lesions after 2 years. - Cognitive functioning at baseline and decline in cognitive function after 2 years - blood pressure (BP) and BP variability	—

Countries

Netherlands

Outcome results